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  • Jean-michel Brunel
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    Main Interests

    Our project teams gather chemists cooperating with and biologists who work on novel target discovery and validation. Our mission is to design and prepare specific inhibitors and/or ligands modulating the effects of proteins in vitro first and in animal model ultimately. In this context, these compounds serve first as pharmacological probe to validate therapeutic approaches and then as drug prototypes. Our know-how is a combination of academic experience. It spans from medicinal chemistry, asymmetric catalysis and organometallic chemistry to achieve our goals in the organoselective synthesis of biologically active molecules. We foster close ties with industrial teams and academic researchers, especially with structural biologists and molecular modellers. We are also open to any collaboration where medicinal chemistry, screening can unlatch new drug research and accelerate the translation of new therapeutic concept into drug discovery.

    Selected publications