CRCM
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    Research Examples

    Raux B, Voitovich Y, Derviaux C, Lugari A, Rebuffet E, Milhas S, Priet S, Roux T, Trinquet E, Guillemot JC, et al.: Exploring Selective Inhibition of the First Bromodomain of the Human Bromodomain and Extra-terminal Domain (BET) Proteins. J Med Chem 2016, 59:1634-1641.

    Milhas S, Raux B, Betzi S, Derviaux C, Roche P, Restouin A, Basse MJ, Rebuffet E, Lugari A, Badol M, et al.: Protein-Protein Interaction Inhibition (2P2I)-Oriented Chemical Library Accelerates Hit Discovery. ACS Chem Biol 2016, 11:2140-2148.

    Basse MJ, Betzi S, Morelli X, Roche P: 2P2Idb v2: update of a structural database dedicated to orthosteric modulation of protein-protein interactions. Database (Oxford) 2016, 2016.

    Moschoi R, Imbert V, Nebout M, Chiche J, Mary D, Prebet T, Saland E, Castellano R, Pouyet L, Collette Y, et al.: Protective mitochondrial transfer from bone marrow stromal cells to acute myeloid leukemic cells during chemotherapy. Blood 2016, 128:253-264.

    Bolla JM, Brunel JM: Enhancing antibiotic activity to combat resistant Gram-negative bacteria: what's next? Future Med Chem 2014, 6:1849-1851.

    Czjzek M, Fierobe HP, Receveur-Bréchot V: Small-angle X-ray scattering and crystallography: a winning combination for exploring the multimodular organization of cellulolytic macromolecular complexes. Methods Enzymol 2012, 510:183-210.

    Publications list (2012-2016)

    2016

    1. Basse MJ, Betzi S, Morelli X, Roche P: 2P2Idb v2: update of a structural database dedicated to orthosteric modulation of protein-protein interactions. Database (Oxford) 2016, 2016.
    2. Blanchet M, Borselli D, Brunel JM: Polyamine derivatives: a revival of an old neglected scaffold to fight resistant Gram-negative bacteria? Future Med Chem 2016, 8:963-973.
    3. Borselli D, Lieutaud A, Thefenne H, Garnotel E, Pagès JM, Brunel JM, Bolla JM: Polyamino-Isoprenic Derivatives Block Intrinsic Resistance of P. aeruginosa to Doxycycline and Chloramphenicol In Vitro. PLoS One 2016, 11:e0154490.
    4. Ebrahimi E, Jarrahpour A, Heidari N, Sinou V, Latour C, Brunel JM, Zolghadr AR, Turos E: Synthesis and antimalarial activity of new nanocopolymer β-lactams and molecular docking study of their monomers. Med Chem Res 2016, 25:247-262.
    5. Jarrahpour A, Shirvani P, Sinou V, Latour C, Brunel JM: Synthesis and biological evaluation of some new β-lactam-triazole hybrids. Med Chem Res 2016, 25:149-162.
    6. Launay H, Barré P, Puppo C, Manneville S, Gontero B, Receveur-Bréchot V: Absence of residual structure in the intrinsically disordered regulatory protein CP12 in its reduced state. Biochem Biophys Res Commun 2016, 477:20-26.
    7. Mikami K, Motoyama Y, Brunel JM, du Jourdin XM: (R)-1,1′-Bi-2,2′-naphthol. In Encyclopedia of Reagents for Organic Synthesis. Edited by: John Wiley & Sons, Ltd; 2016:1-23.
    8. Milhas S, Raux B, Betzi S, Derviaux C, Roche P, Restouin A, Basse MJ, Rebuffet E, Lugari A, Badol M, et al.: Protein-Protein Interaction Inhibition (2P2I)-Oriented Chemical Library Accelerates Hit Discovery. ACS Chem Biol 2016, 11:2140-2148.
    9. Moschoi R, Imbert V, Nebout M, Chiche J, Mary D, Prebet T, Saland E, Castellano R, Pouyet L, Collette Y, et al.: Protective mitochondrial transfer from bone marrow stromal cells to acute myeloid leukemic cells during chemotherapy. Blood 2016, 128:253-264.
    10. Puvirajesinghe TM, Bertucci F, Jain A, Scerbo P, Belotti E, Audebert S, Sebbagh M, Lopez M, Brech A, Finetti P, et al.: Identification of p62/SQSTM1 as a component of non-canonical Wnt VANGL2-JNK signalling in breast cancer. Nat Commun 2016, 7:10318.
    11. Raux B, Voitovich Y, Derviaux C, Lugari A, Rebuffet E, Milhas S, Priet S, Roux T, Trinquet E, Guillemot JC, et al.: Exploring Selective Inhibition of the First Bromodomain of the Human Bromodomain and Extra-terminal Domain (BET) Proteins. J Med Chem 2016, 59:1634-1641.

    2015

    1. Bakour S, Garcia V, Loucif L, Brunel JM, Gharout-Sait A, Touati A, Rolain JM: Rapid identification of carbapenemase-producing Enterobacteriaceae, Pseudomonas aeruginosa and Acinetobacter baumannii using a modified Carba NP test. New Microbes New Infect 2015, 7:89-93.
    2. Bonzi J, Bornet O, Betzi S, Kasper BT, Mahal LK, Mancini SJ, Schiff C, Sebban-Kreuzer C, Guerlesquin F, Elantak L: Pre-B cell receptor binding to galectin-1 modifies galectin-1/carbohydrate affinity to modulate specific galectin-1/glycan lattice interactions. Nat Commun 2015, 6:6194.
    3. Collette Y, Prébet T, Goubard A, Adélaïde J, Castellano R, Carbuccia N, Garnier S, Guille A, Arnoulet C, Charbonier A, et al.: Drug response profiling can predict response to ponatinib in a patient with t(1;9)(q24;q34)-associated B-cell acute lymphoblastic leukemia. Blood Cancer J 2015, 5:e292.
    4. Coppin E, Gelsi-Boyer V, Morelli X, Cervera N, Murati A, Pandolfi PP, Birnbaum D, Nunès JA: Mutational analysis of the DOK2 haploinsufficient tumor suppressor gene in chronic myelomonocytic leukemia (CMML). Leukemia 2015, 29:500-502.
    5. Coulibaly O, Thera MA, Koné AK, Siaka G, Traoré P, Djimdé AA, Brunel JM, Gaudart J, Piarroux R, Doumbo OK, et al.: A double-blind randomized placebo-controlled clinical trial of squalamine ointment for tinea capitis treatment. Mycopathologia 2015, 179:187-193.
    6. Fouqué A, Delalande O, Jean M, Castellano R, Josselin E, Malleter M, Shoji KF, Hung MD, Rampanarivo H, Collette Y, et al.: A Novel Covalent mTOR Inhibitor, DHM25, Shows in Vivo Antitumor Activity against Triple-Negative Breast Cancer Cells. J Med Chem 2015, 58:6559-6573.
    7. Hu F, Shi X, Li B, Huang X, Morelli X, Shi N: Structural basis for the interaction between the Golgi reassembly-stacking protein GRASP65 and the Golgi matrix protein GM130. J Biol Chem 2015, 290:26373-26382.
    8. Imperiale A, Moussallieh FM, Roche P, Battini S, Cicek AE, Sebag F, Brunaud L, Barlier A, Elbayed K, Loundou A, et al.: Metabolome Profiling by HRMAS NMR Spectroscopy of Pheochromocytomas and Paragangliomas Detects SDH Deficiency: Clinical and Pathophysiological Implications. Neoplasia 2015, 17:55-65.
    9. Jarrahpour A, Aye M, Sinou V, Latour C, Brunel JM: Synthesis of some new monocyclic β-lactams as antimalarial agents. J Iran Chem Soc 2015, 12:2083-2092.
    10. Jarrahpour A, Shirvani P, Sharghi H, Aberi M, Sinou V, Latour C, Brunel JM: Synthesis of novel mono- and bis-Schiff bases of morpholine derivatives and the investigation of their antimalarial and antiproliferative activities. Med Chem Res 2015, 24:4105-4112.
    11. Ochsenbein F, Morelli X, Verma C: Editorial. Protein-Protein Interaction Analysis and Modulation. Prog Biophys Mol Biol 2015, 119:1.
    12. Olesen SH, Ingles DJ, Zhu JY, Martin MP, Betzi S, Georg GI, Tash JS, Schönbrunn E: Stability of the human Hsp90-p50Cdc37 chaperone complex against nucleotides and Hsp90 inhibitors, and the influence of phosphorylation by casein kinase 2. Molecules 2015, 20:1643-1660.
    13. Pieri C, Brunel JM: First Efficient Two-Step/One-Pot Zirconium (IV)isopropoxide–Mediated Reductive Amination of Carbonyl Compounds. Lett Drug Des Discov 2015, 12:448-456.
    14. Qin Z, Pandey NR, Zhou X, Stewart CA, Hari A, Huang H, Stewart AF, Brunel JM, Chen HH: Functional properties of Claramine: a novel PTP1B inhibitor and insulin-mimetic compound. Biochem Biophys Res Commun 2015, 458:21-27.
    15. Qin Z, Zhou X, Pandey NR, Vecchiarelli HA, Stewart CA, Zhang X, Lagace DC, Brunel JM, Béïque JC, Stewart AF, et al.: Chronic stress induces anxiety via an amygdalar intracellular cascade that impairs endocannabinoid signaling. Neuron 2015, 85:1319-1331.
    16. Saland E, Boutzen H, Castellano R, Pouyet L, Griessinger E, Larrue C, de Toni F, Scotland S, David M, Danet-Desnoyers G, et al.: A robust and rapid xenograft model to assess efficacy of chemotherapeutic agents for human acute myeloid leukemia. Blood Cancer J 2015, 5:e297.
    17. Sitnikov NS, Sinzov AV, Allegro D, Barbier P, Combes S, Onambele LA, Prokop A, Schmalz H-G, Fedorov AY: Synthesis of indole-derived allocolchicine congeners exhibiting pronounced anti-proliferative and apoptosis-inducing properties. MedChemComm 2015, 6:2158-2162.
    18. Sperandio O, Villoutreix BO, Morelli X, Roche P: Chemical libraries dedicated to protein-protein interactions. Med Sci (Paris) 2015, 31:312-319.
    19. Thomas E, Sircaik S, Roman E, Brunel JM, Johri AK, Pla J, Panwar SL: The activity of RTA2, a downstream effector of the calcineurin pathway, is required during tunicamycin-induced ER stress response in Candida albicans. FEMS Yeast Res 2015, 15.
    20. Voitovich YV, Shegravina ES, Sitnikov NS, Faerman VI, Fokin VV, Schmalz HG, Combes S, Allegro D, Barbier P, Beletskaya IP, et al.: Synthesis and biological evaluation of furanoallocolchicinoids. J Med Chem 2015, 58:692-704.

    2014

    1. Alhanout K, Giorgio CD, Meo MD, Brunel JM: Non-Genotoxic Assessment of a Natural Antimicrobial Agent: Squalamine. Antiinfect Agents Med Chem 2014, 12:75-79.
    2. Birol M, Enchev RI, Padilla A, Stengel F, Aebersold R, Betzi S, Yang Y, Hoh F, Peter M, Dumas C, et al.: Structural and biochemical characterization of the Cop9 signalosome CSN5/CSN6 heterodimer. PLoS One 2014, 9:e105688.
    3. Bolla JM, Brunel JM: Enhancing antibiotic activity to combat resistant Gram-negative bacteria: what's next? Future Med Chem 2014, 6:1849-1851.
    4. Bornet O, Nouailler M, Feracci M, Sebban-Kreuzer C, Byrne D, Halimi H, Morelli X, Badache A, Guerlesquin F: Identification of a Src kinase SH3 binding site in the C-terminal domain of the human ErbB2 receptor tyrosine kinase. FEBS Lett 2014, 588:2031-2036.
    5. Bouvet M, Lugari A, Posthuma CC, Zevenhoven JC, Bernard S, Betzi S, Imbert I, Canard B, Guillemot JC, Lécine P, et al.: Coronavirus Nsp10, a critical co-factor for activation of multiple replicative enzymes. J Biol Chem 2014, 289:25783-25796.
    6. Champelovier P, Barbier P, Daras E, Douillard S, Toussaint B, Persoon V, Curri V, Peyrot V, Combes S: The Indolylcoumarin COUFIN Exhibits Potent Activity Against Renal Carcinoma Cells without Affecting Hematopoietic System. Anticancer Agents Med Chem 2014, 14:862-871.
    7. Contesto-Richefeu C, Tarbouriech N, Brazzolotto X, Betzi S, Morelli X, Burmeister WP, Iseni F: Crystal structure of the vaccinia virus DNA polymerase holoenzyme subunit D4 in complex with the A20 N-terminal domain. PLoS Pathog 2014, 10:e1003978.
    8. De Bellis F, Carafa V, Conte M, Rotili D, Petraglia F, Matarese F, Françoijs KJ, Ablain J, Valente S, Castellano R, et al.: Context-selective death of acute myeloid leukemia cells triggered by the novel hybrid retinoid-HDAC inhibitor MC2392. Cancer Res 2014, 74:2328-2339.
    9. Djouhri-Bouktab L, Rolain JM, Brunel JM: Mini-Review: Polyamines Metabolism, Toxicity and Potent Therapeutical Use. Antiinfect Agents Med Chem 2014, 12:95-103.
    10. Hamon V, Bourgeas R, Ducrot P, Theret I, Xuereb L, Basse MJ, Brunel JM, Combes S, Morelli X, Roche P: 2P2I HUNTER: a tool for filtering orthosteric protein-protein interaction modulators via a dedicated support vector machine. J R Soc Interface 2014, 11:20130860.
    11. Jarrahpour A, Ebrahimi E, Sinou V, Latour C, Brunel JM: Diastereoselective synthesis of potent antimalarial cis-β-lactam agents through a [2 + 2] cycloaddition of chiral imines with a chiral ketene. Eur J Med Chem 2014, 87:364-371.
    12. Khelifi N, Amin Ali O, Roche P, Grossi V, Brochier-Armanet C, Valette O, Ollivier B, Dolla A, Hirschler-Réa A: Anaerobic oxidation of long-chain n-alkanes by the hyperthermophilic sulfate-reducing archaeon, Archaeoglobus fulgidus. ISME J 2014, 8:2153-2166.
    13. Loosveld M, Castellano R, Gon S, Goubard A, Crouzet T, Pouyet L, Prebet T, Vey N, Nadel B, Collette Y, et al.: Therapeutic targeting of c-Myc in T-cell acute lymphoblastic leukemia, T-ALL. Oncotarget 2014, 5:3168-3172.
    14. Pandey NR, Zhou X, Zaman T, Cruz SA, Qin Z, Lu M, Keyhanian K, Brunel JM, Stewart AF, Chen HH: LMO4 is required to maintain hypothalamic insulin signaling. Biochem Biophys Res Commun 2014, 450:666-672.
    15. Pieri C, Borselli D, Di Giorgio C, De Méo M, Bolla JM, Vidal N, Combes S, Brunel JM: New Ianthelliformisamine derivatives as antibiotic enhancers against resistant Gram-negative bacteria. J Med Chem 2014, 57:4263-4272.
    16. Pieri C, Combes S, Brunel JM: First evidence for the use of polyamines as nucleophiles in a regioselective palladium-catalyzed allylic amination reaction. Tetrahedron 2014, 70:9718-9725.
    17. Wang Y, Longhi S, Roche P, Wang J: Reply to Jensen and Blackledge: Dual quantifications of intrinsically disordered proteins by NMR ensembles and molecular dynamics simulations. Proc Natl Acad Sci U S A 2014, 111:E1559.
    18. Zhang X, Betzi S, Morelli X, Roche P: Focused chemical libraries--design and enrichment: an example of protein-protein interaction chemical space. Future Med Chem 2014, 6:1291-1307.

    2013

    1. Basse MJ, Betzi S, Bourgeas R, Bouzidi S, Chetrit B, Hamon V, Morelli X, Roche P: 2P2Idb: a structural database dedicated to orthosteric modulation of protein-protein interactions. Nucleic Acids Res 2013, 41:D824-827.
    2. Breuer S, Espinola S, Morelli X, Torbett BE, Arold ST, Engels IH: A Biochemical/Biophysical Assay Dyad for HTS-Compatible Triaging of Inhibitors of the HIV-1 Nef/Hck SH3 Interaction. Curr Chem Genom Transl Med 2013, 7:16-20.
    3. Brunel JM, Lieutaud A, Lome V, Pagès JM, Bolla JM: Polyamino geranic derivatives as new chemosensitizers to combat antibiotic resistant gram-negative bacteria. Bioorg Med Chem 2013, 21:1174-1179.
    4. Chaubet G, Coursindel T, Morelli X, Betzi S, Roche P, Guari Y, Lebrun A, Toupet L, Collette Y, Parrot I, et al.: Stereoselective synthesis of original spirolactams displaying promising folded structures. Org Biomol Chem 2013, 11:4719-4726.
    5. Coulibaly O, Alhanout K, L'Ollivier C, Brunel JM, Thera MA, Djimdé AA, Doumbo OK, Piarroux R, Ranque S: In vitro activity of aminosterols against dermatophytes. Med Mycol 2013, 51:309-312.
    6. Ghodbane R, Ameen SM, Drancourt M, Brunel JM: In vitro antimicrobial activity of squalamine derivatives against mycobacteria. Tuberculosis (Edinb) 2013, 93:565-566.
    7. Hamon V, Brunel JM, Combes S, Basse MJ, Roche P, Morelli X: 2P2Ichem: Focused Chemical Libraries Dedicated to Orthosteric Modulation of Protein-Protein Interactions. MedChemComm 2013, 4:797-809.
    8. Hamon V, Morelli X: Druggability of protein-protein interactions. In Understanding and Exploiting Protein-Protein Interactions as Drug Targets. Edited by: Future Science Ltd; 2013:18-31. Future Science Book Series
    9. Hraiech S, Roch A, Lepidi H, Atieh T, Audoly G, Rolain JM, Raoult D, Brunel JM, Papazian L, Brégeon F: Impaired virulence and fitness of a colistin-resistant clinical isolate of Acinetobacter baumannii in a rat model of pneumonia. Antimicrob Agents Chemother 2013, 57:5120-5121.
    10. Ivarsson Y, Wawrzyniak AM, Kashyap R, Polanowska J, Betzi S, Lembo F, Vermeiren E, Chiheb D, Lenfant N, Morelli X, et al.: Prevalence, specificity and determinants of lipid-interacting PDZ domains from an in-cell screen and in vitro binding experiments. PLoS One 2013, 8:e54581.
    11. Khelaifia S, Brunel JM, Michel JB, Drancourt M: In-vitro archaeacidal activity of biocides against human-associated archaea. PLoS One 2013, 8:e62738.
    12. Khelaifia S, Brunel JM, Raoult D, Drancourt M: Hydrophobicity of imidazole derivatives correlates with improved activity against human methanogenic archaea. Int J Antimicrob Agents 2013, 41:544-547.
    13. Lieutaud A, Lorenzi V, Giuliani MC, Brunel JM, Luciani A, Casanova J, Pages JM, LBerti L, Bolla JM: Inhibitors of Antibiotic Efflux by AcrAB-TolC in Enterobacter aerogenes. Antiinfect Agents Med Chem 2013, 11:168-178.
    14. Malleter M, Tauzin S, Bessede A, Castellano R, Goubard A, Godey F, Levêque J, Jézéquel P, Campion L, Campone M, et al.: CD95L cell surface cleavage triggers a prometastatic signaling pathway in triple-negative breast cancer. Cancer Res 2013, 73:6711-6721.
    15. Malysheva YB, Voitovich YV, Sharonova EA, Combes S, Svirshchevskaya EV, Vodovozova EL, Fedorov AY: Novel water-soluble anticancer agents derived from 4-arylcoumarins. Russ Chem B+ 2013, 62:1103-1110.
    16. Pandey NR, Zhou X, Qin Z, Zaman T, Gomez-Smith M, Keyhanian K, Anisman H, Brunel JM, Stewart AF, Chen HH: The LIM domain only 4 protein is a metabolic responsive inhibitor of protein tyrosine phosphatase 1B that controls hypothalamic leptin signaling. J Neurosci 2013, 33:12647-12655.
    17. Poggi M, Kara I, Brunel JM, Landrier JF, Govers R, Bonardo B, Fluhrer R, Haass C, Alessi MC, Peiretti F: Palmitoylation of TNF alpha is involved in the regulation of TNF receptor 1 signalling. Biochim Biophys Acta 2013, 1833:602-612.
    18. Roblin P, Lebrun P, Rucktooa P, Dewitte F, Lens Z, Receveur-Brechot V, Raussens V, Villeret V, Bompard C: The structural organization of the N-terminus domain of SopB, a virulence factor of Salmonella, depends on the nature of its protein partners. Biochim Biophys Acta 2013, 1834:2564-2572.
    19. Salvador MA, Wicinski J, Cabaud O, Toiron Y, Finetti P, Josselin E, Lelièvre H, Kraus-Berthier L, Depil S, Bertucci F, et al.: The histone deacetylase inhibitor abexinostat induces cancer stem cells differentiation in breast cancer with low Xist expression. Clin Cancer Res 2013, 19:6520-6531.
    20. Schonbrunn E, Betzi S, Alam R, Martin MP, Becker A, Han H, Francis R, Chakrasali R, Jakkaraj S, Kazi A, et al.: Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases. J Med Chem 2013, 56:3768-3782.
    21. Wang Y, Chu X, Longhi S, Roche P, Han W, Wang E, Wang J: Multiscaled exploration of coupled folding and binding of an intrinsically disordered molecular recognition element in measles virus nucleoprotein. Proc Natl Acad Sci U S A 2013, 110:E3743-3752.

    2012

    1. Biswas S, Brunel JM, Dubus JC, Reynaud-Gaubert M, Rolain JM: Colistin: an update on the antibiotic of the 21st century. Expert Rev Anti Infect Ther 2012, 10:917-934.
    2. Brunel JM, Salmi-Smail C, Restouin A, Prebet T, Vey N, Collette Y: Design of N-substituted amino caproic hydroxamic acid histone deacetylase inhibitors reveal an essential role for cap atomic composition. Anticancer Agents Med Chem 2012, 12:801-806.
    3. Chaib H, Nebbioso A, Prebet T, Castellano R, Garbit S, Restouin A, Vey N, Altucci L, Collette Y: Anti-leukemia activity of chaetocin via death receptor-dependent apoptosis and dual modulation of the histone methyl-transferase SUV39H1. Leukemia 2012, 26:662-674.
    4. Czjzek M, Fierobe HP, Receveur-Bréchot V: Small-angle X-ray scattering and crystallography: a winning combination for exploring the multimodular organization of cellulolytic macromolecular complexes. Methods Enzymol 2012, 510:183-210.
    5. Daughdrill GW, Kashtanov S, Stancik A, Hill SE, Helms G, Muschol M, Receveur-Bréchot V, Ytreberg FM: Understanding the structural ensembles of a highly extended disordered protein. Mol Biosyst 2012, 8:308-319.
    6. Djouhri-Bouktab L, Alhanout K, Andrieu V, Stremler N, Dubus JC, Raoult D, Rolain JM, Brunel JM: Soluble squalamine tablets for the rapid disinfection of home nebulizers of cystic fibrosis patients. J Cyst Fibros 2012, 11:555-559.
    7. Elantak L, Espeli M, Boned A, Bornet O, Bonzi J, Gauthier L, Feracci M, Roche P, Guerlesquin F, Schiff C: Structural basis for galectin-1-dependent pre-B cell receptor (pre-BCR) activation. J Biol Chem 2012, 287:44703-44713.
    8. Gertner-Dardenne J, Castellano R, Mamessier E, Garbit S, Kochbati E, Etienne A, Charbonnier A, Collette Y, Vey N, Olive D: Human Vγ9Vδ2 T cells specifically recognize and kill acute myeloid leukemic blasts. J Immunol 2012, 188:4701-4708.
    9. Hraiech S, Brégeon F, Brunel JM, Rolain JM, Lepidi H, Andrieu V, Raoult D, Papazian L, Roch A: Antibacterial efficacy of inhaled squalamine in a rat model of chronic Pseudomonas aeruginosa pneumonia. J Antimicrob Chemother 2012, 67:2452-2458.
    10. Jarrahpour A, Ebrahimi E, Khalifeh R, Sharghi H, Sahraei M, Sinou V, Latour C, Brunel JM: Synthesis of novel β-lactams bearing an anthraquinone moiety, and evaluation of their antimalarial activities. Tetrahedron 2012, 68:4740-4744.
    11. Kempf M, Bakour S, Flaudrops C, Berrazeg M, Brunel JM, Drissi M, Mesli E, Touati A, Rolain JM: Rapid detection of carbapenem resistance in Acinetobacter baumannii using matrix-assisted laser desorption ionization-time of flight mass spectrometry. PLoS One 2012, 7:e31676.
    12. Kempf M, Djouhri-Bouktab L, Brunel JM, Raoult D, Rolain JM: Synergistic activity of sulbactam combined with colistin against colistin-resistant Acinetobacter baumannii. Int J Antimicrob Agents 2012, 39:180-181.
    13. Malysheva YB, Combes S, Allegro D, Peyrot V, Knochel P, Gavryushin AE, Fedorov AY: Synthesis and biological evaluation of novel anticancer bivalent colchicine-tubulizine hybrids. Bioorg Med Chem 2012, 20:4271-4278.
    14. Malysheva YB, Combes S, Fedorov AY, Knochel P, Gavryushin AE: New Method of Synthesis and Biological Evaluation of Some Combretastatin A-4 Analogues. Synlett 2012, 23:1205-1208.
    15. Martin MP, Alam R, Betzi S, Ingles DJ, Zhu JY, Schönbrunn E: A novel approach to the discovery of small-molecule ligands of CDK2. Chembiochem 2012, 13:2128-2136.
    16. Mezil L, Berruyer-Pouyet C, Cabaud O, Josselin E, Combes S, Brunel JM, Viens P, Collette Y, Birnbaum D, Lopez M: Tumor selective cytotoxic action of a thiomorpholin hydroxamate inhibitor (TMI-1) in breast cancer. PLoS One 2012, 7:e43409.
    17. Morelli X, Hupp T: Searching for the Holy Grail; protein-protein interaction analysis and modulation. EMBO Rep 2012, 13:877-879.
    18. Moucadel V, Prudent R, Sautel CF, Teillet F, Barette C, Lafanechere L, Receveur-Brechot V, Cochet C: Antitumoral activity of allosteric inhibitors of protein kinase CK2. Oncotarget 2011, 2:997-1010.
    19. Mouseeva EV, Kuznetsova NR, Svirshchevskaia EV, Bovin NV, Sitnikov NC, Shavyrin AS, Beletskaia IP, Combes S, Fedorov AIu, Vodovozova EL: [Liposome formulations of combretastatin A4 and 4-arylcoumarin analog prodrugs: antitumor effect in the mouse model of breast cancer]. Biomed Khim 2012, 58:326-338.
    20. Receveur-Brechot V, Durand D: How random are intrinsically disordered proteins? A small angle scattering perspective. Curr Protein Pept Sci 2012, 13:55-75.
    21. Shi X, Betzi S, Lugari A, Opi S, Restouin A, Parrot I, Martinez J, Zimmermann P, Lecine P, Huang M, et al.: Structural recognition mechanisms between human Src homology domain 3 (SH3) and ALG-2-interacting protein X (Alix). FEBS Lett 2012, 586:1759-1764.
    22. Stocker P, Brunel JM, de Rezende L, -do Amaral AT, Morelli X, Roche P, Vidal N, Giardina T, Perrier J: Aminoacylase 1-catalysed deacetylation of bioactives epoxides mycotoxin-derived mercapturates; 3,4-epoxyprecocenes as models of cytotoxic epoxides. Biochimie 2012, 94:1668-1675.
    23. Veuillen C, Aurran-Schleinitz T, Castellano R, Rey J, Mallet F, Orlanducci F, Pouyet L, Just-Landi S, Coso D, Ivanov V, et al.: Primary B-CLL resistance to NK cell cytotoxicity can be overcome in vitro and in vivo by priming NK cells and monoclonal antibody therapy. J Clin Immunol 2012, 32:632-646.
    24. Ysacco C, Karoui H, Casano G, Le Moigne F, Combes S, Rockenbauer A, Rosay M, Maas W, Ouari O, Tordo P: Dinitroxides for Solid State Dynamic Nuclear Polarization. Appl Magn Reson 2012, 43:251-261.
    25. Zhu JY, Yang Y, Han H, Betzi S, Olesen SH, Marsilio F, Schönbrunn E: Functional consequence of covalent reaction of phosphoenolpyruvate with UDP-N-acetylglucosamine 1-carboxyvinyltransferase (MurA). J Biol Chem 2012, 287:12657-12667.